The National Institutes of Health is accepting applications for its Pragmatic Clinical Trials in Community Settings to Decrease or Prevent VCID Outcomes, Including in Populations that Experience Health Disparities.
Donor Name: National Institutes of Health
State: All States
County: All Counties
Type of Grant: Grant
Deadline: 09/15/2022
Size of the Grant: $6,000,000
Grant Duration: 5 years
Details:
The purpose of this FOA is to invite applications for PCTs designed to decrease or prevent negative clinical outcomes associated with VCID by targeting modifiable risk factors in locally representative NIH defined populations that experience health disparities in dementia. Recent studies have demonstrated that in a controlled research environment, interventions targeting modifiable risk factors have the potential to prevent or slow the development of cognitive impairment including dementia. For example, the NIH-funded SPRINT-MIND trial demonstrated that intensive blood pressure control in a population of adults over age 50 years significantly decreased the risk of mild cognitive impairment and the combined risk of mild cognitive impairment or probable dementia. Despite the large body of evidence to suggest cardiovascular risk factors related to diet, exercise and blood pressure control are associated with VCID and other brain health outcomes, hypertension, obesity, and a sedentary lifestyle are common among the US population and there has not been widespread uptake of interventions to reduce risk. The CDC estimates that nearly half of US adults have hypertension, and only a quarter of those have blood pressure that is well controlled. Black Americans are more likely than Whites Americans to suffer from hypertension and less likely to have blood pressure be well controlled. Rates of dementia have been found to be higher among Black and Hispanic Americans, and data from the NIH-funded REGARDS epidemiologic study suggests that cardiovascular risk may be associated with worse cognitive outcomes among Black as compared to White Americans. Compounding these problems, racial and ethnic minority populations are significantly underrepresented in dementia research.
Funding Information
- NINDS intends to commit an estimated total of $6,000,000 to fund up to 3 awards.
- The maximum project period is five years.
Eligibility Criteria
- Higher Education Institutions
- Public/State Controlled Institutions of Higher Education
- Private Institutions of Higher Education
- The following types of Higher Education Institutions are always encouraged to apply for NIH support as Public or Private Institutions of Higher Education:
- Hispanic-serving Institutions
- Historically Black Colleges and Universities (HBCUs)
- Tribally Controlled Colleges and Universities (TCCUs)
- Alaska Native and Native Hawaiian Serving Institutions
- Asian American Native American Pacific Islander Serving Institutions (AANAPISIs)
- Nonprofits Other Than Institutions of Higher Education
- Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Higher Education)
- Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education)
- For-Profit Organizations
- Small Businesses
- For-Profit Organizations (Other than Small Businesses)
- Local Governments
- State Governments
- County Governments
- City or Township Governments
- Special District Governments
- Indian/Native American Tribal Governments (Federally Recognized)
- Indian/Native American Tribal Governments (Other than Federally Recognized)
- Federal Government
- Eligible Agencies of the Federal Government
- U.S. Territory or Possession
- Other
- Independent School Districts
- Public Housing Authorities/Indian Housing Authorities
- Native American Tribal Organizations (other than Federally recognized tribal governments)
- Faith-based or Community-based Organizations
- Regional Organizations
For more information, visit Grants.gov.
