The National Institutes of Health is seeking applications that propose large-scale, complex research projects with multiple highly integrated components focused on a common research question relevant to aging.
Donor Name: National Institutes of Health
State: All States
County: All Counties
Territory: Commonwealth of Puerto Rico, the U.S. Virgin Islands, Guam, American Samoa, the Commonwealth of the Northern Mariana Islands
Type of Grant: Grant
Deadline: 09/25/2025
Grant Duration: 5 years
Details:
Purpose
This FOA allows for applications that propose large-scale, complex research projects with multiple highly integrated components focused on a common research question relevant to aging. Such projects will likely involve an integrated multidisciplinary team of investigators within a single institution or a consortium of institutions.
Scope
This FOA invites applications that propose large-scale, complex research projects with multiple highly integrated components focused on a common research question relevant to aging. Such projects will likely involve an integrated multidisciplinary team of investigators within a single institution or a consortium of institutions. Resources and study expertise will be tightly coordinated across multiple sites or cores, such as:
- One or more coordinating centers
- Clinical or study sites
- Specialized cores, such as for data management and analysis, measurement and phenotyping, animal models, etc.
Examples of the kinds of studies supported under this announcement include, but are not limited to, one or a combination of the following:
- Large-scale longitudinal observational studies of diseases or conditions that are common in aging populations involving integration of multiple clinical outcomes with molecular, genetic, or other mechanistic data.
- Large-scale, multi-site intervention studies in human subjects and/or animal models for aging-related conditions involving multiple endpoints to assess efficacy or effectiveness of gerotherapeutic or geroprotective interventions and to elucidate mechanisms.
- Complex research programs on interactions among the underlying molecular causes of aging, and on changes in inter-organ communication as drivers of aging.
- Large-scale, multidisciplinary geroscience studies with human participants and/or animal models of aging to elucidate cellular, molecular, and integrated physiological mechanisms, identify influencers of health, environmental and other factors impacting health outcomes including Social Determinants of Health, and determine potential clinical targets to delay or prevent aging related multimorbidity.
- Large-scale, complex research projects with multiple highly integrated components focused on a common research question relevant to aging and diseases of brain aging, particularly studies focused on Alzheimer’s disease (AD) and Alzheimer’s disease-related dementias (ADRD).
- Large-scale, multidisciplinary behavioral and social science studies of aging that might examine mechanistic pathways at multiple levels of analysis across the lifespan, especially those that could identify and explain risk and protective factors related to physical, cognitive, and emotional health outcomes that might lead to the development of future interventions to improve the health and well-being of older populations.
- Comprehensive, integrative, and/or multidisciplinary studies using a range of scientific approaches to examine mechanisms underlying brain aging and AD/ADRD.
- Translation of basic science findings into pre-clinical or clinical studies, or of clinical findings into practice or community settings, for prevention, diagnosis, or treatment of aging-related conditions, requiring coordination of broad multidisciplinary expertise across multiple settings.
Grant Period
The maximum project period is 5 years.
Eligibility Criteria
- Higher Education Institutions
- Public/State Controlled Institutions of Higher Education
- Private Institutions of Higher Education
- The following types of Higher Education Institutions are always encouraged to apply for NIH support as Public or Private Institutions of Higher Education:
- Nonprofits Other Than Institutions of Higher Education
- Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Higher Education)
- Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education)
- For-Profit Organizations
- Small Businesses
- For-Profit Organizations (Other than Small Businesses)
- Local Governments
- State Governments
- County Governments
- City or Township Governments
- Special District Governments
- Indian/Native American Tribal Governments (Federally Recognized)
- Indian/Native American Tribal Governments (Other than Federally Recognized)
- Federal Governments
- Eligible Agencies of the Federal Government
- U.S. Territory or Possession.
For more information, visit Grants.gov.
