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You are here: Home / Grant Size / $1 Million to $50 Million / HEAL Initiative: Sleep Predictors of Opioid-Use Disorder Treatment Outcomes Program

HEAL Initiative: Sleep Predictors of Opioid-Use Disorder Treatment Outcomes Program

Dated: November 16, 2022

The National Institutes of Health (NIH) is soliciting proposals for its Sleep Predictors of Opioid-Use Disorder Treatment Outcomes Program.

Donor Name: National Institutes of Health (NIH)

State: All States

County: All Counties

U.S. Territories: U.S. Virgin Islands, Commonwealth of the Northern Mariana Islands, American Samoa, Commonwealth of Puerto Rico, Guam

Type of Grant: Grant

Deadline: 01/10/2023

Size of the Grant: $3M

Grant Duration: 4 years

Details:

Opioid use disorders (OUDs) and disorders of sleep and/or circadian rhythm are intricately interconnected. Opioids have a disruptive effect on sleep and sleep quality, while sleep and circadian rhythm disturbances contribute to initiating and maintaining drug use and can increase the risk for relapse. Acute drug use disrupts sleep architecture, latency, duration, and quality. With chronic use, sleep disruptions intensify, and withdrawal is often associated with sleep fragmentation. Such alterations in sleep resemble chronic insomnia, which is a well-known risk factor for relapse to substance use. There is a complex feed-forward relationship between sleep disturbances and drug use. Multiple neural substrates, circuits, and cognitive mechanisms that govern the regulation of arousal and sleep homeostasis, overlap with those governing substance use disorder, including reward/reinforcement, physical dependence, and withdrawal.

The overall goals of this funding opportunity are: To support clinical research project applications that mechanistically explore the relationship between sleep and/or circadian rhythms and OUD (clinical site-specific projects), and develop data-science based predictive model/s using sleep and circadian parameters that can be applied to predict individual OUD treatment responses and the susceptibility to relapse. Will be accomplished by individual site-specific studies and by contribution of data from individual sites to a common protocol for the development of predictive algorithms by a Leadership and Data Coordinating Center (LDCC) (see companion FOA).

Research areas of programmatic interest for site-specific studies include, but are not limited to:

  • Elucidating neurobiological mechanisms through which sleep deficiency modifies reward, affect, executive function, pain, and susceptibility to OUD.
    • Identifying mechanisms by which sleep deficiency modifies opioid withdrawal, overdose, or the course of recovery.
    • Investigating mechanisms through which sleep deficiency mediates OUD medication treatment response.
  • Delineating pharmacological mechanisms mediating the effects of acute and chronic administration of opioids on sleep parameters.
  • Investigating mechanisms through which medications to treat OUD (e.g., buprenorphine, methadone) affect sleep regulation and circadian rhythms.
  • Examining mechanisms underlying the effects of opioid withdrawal on sleep parameters
  • Examining behavioral and pharmacological means of targeting sleep deficiency for prevention or treatment of OUD or OUD susceptibility.
  • Examining mechanisms by which pharmacological or non-pharmacological alterations of sleep parameters mediate the efficacy and safety of MOUD
  • Identifying key neurochemical and sleep architecture changes across the trajectory of opioid use and MOUDthat mediate and can be used as biomarkers of addiction, recovery and/or relapse.
  • Examining circadian-dependent pharmacological mechanisms contributing to opioid tolerance, withdrawal, and
  • MOUDresponse (e.g., does effectiveness vary depending on time of day of administration?).
  • Elucidating the role of endogenous opioid systems in sleep and circadian rhythm abnormalities throughout a trajectory of opioid use.

Responsiveness: Applications which lack the following required components will be deemed nonresponsive to this FOA and returned without review:

  • Site-specific research applications must explore mechanisms underlying the interrelationship between sleep and/or circadian rhythms and OUD. Applications without a mechanistic focus, that are strictly observational, epidemiologic, interventional, or those that include any studies using animals or other in vitro model systems will be considered nonresponsive.
  • Data contribution to the common protocol must include EEG-based measurements.

Award Budget

Application budget for the site-specific projects will be limited to a total of $3M in direct costs. The proposed budget needs to reflect the actual needs of the proposed project.

Award Project Period

The maximum project period is four years.

Eligibility Information

Higher Education Institutions

  • Public/State Controlled Institutions of Higher Education
  • Private Institutions of Higher Education

The following types of Higher Education Institutions are always encouraged to apply for NIH support as Public or Private Institutions of Higher Education:

  • Hispanic-serving Institutions
  • Historically Black Colleges and Universities (HBCUs)
  • Tribally Controlled Colleges and Universities (TCCUs)
  • Alaska Native and Native Hawaiian Serving Institutions
  • Asian American Native American Pacific Islander Serving Institutions (AANAPISIs)

Nonprofits Other Than Institutions of Higher Education

  • Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Higher Education)
  • Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education)

For-Profit Organizations

  • Small Businesses
  • For-Profit Organizations (Other than Small Businesses)

Local Governments

  • State Governments
  • County Governments
  • City or Township Governments
  • Special District Governments
  • Indian/Native American Tribal Governments (Federally Recognized)
  • Indian/Native American Tribal Governments (Other than Federally Recognized)

Federal Government

  • Eligible Agencies of the Federal Government
  • U.S. Territory or Possession

Other

  • Independent School Districts
  • Public Housing Authorities/Indian Housing Authorities
  • Native American Tribal Organizations (other than Federally recognized tribal governments)
  • Faith-based or Community-based Organizations
  • Regional Organizations

Foreign Institutions

  • Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply.
  • Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.
  • Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

For more information, visit Grants.gov.

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