This Funding Opportunity Announcement (FOA) invites applications to examine the molecular mechanisms and consequences of age-related alterations in interorgan communication.
Donor Name: National Institutes of Health
State: All States
County: All Counties
Territory: American Samoa, Commonwealth of Puerto Rico, Commonwealth of the Northern Mariana Islands, Guam, and U.S. Virgin Islands
Type of Grant: Grant
Deadline: 04/01/2023
Size of the Grant: $400,000
Grant Duration: 5 years
Details:
Purpose
This FOA invites applications to examine the molecular mechanisms and consequences of age-related alterations in IOC. Elucidation of the mechanisms that modulate and coordinate organ interactions, and their changes with age, may provide new insights into multimorbidities. Additionally, such research may provide a broader understanding of the complexity and heterogeneity of aging.
Objectives
The goal of this FOA is to promote research that examines the mechanisms of age-related alterations in IOC. Changes in IOC are likely to contribute significantly to the heterogeneity of aging observed in all populations and are likely key factors leading to a range of multimorbidities. Multimorbidities are a serious medical burden, are increasing globally as the proportion of people over 65 years of age continues to rise dramatically, and are of increasing importance in geroscience. Accordingly, elucidation of the mechanisms that modulate and coordinate organ interactions, and their changes with age, may provide new insights into multimorbidities. Further, such research may be essential to obtain a broader understanding of the complexity and heterogeneity of aging.
This FOA focuses on molecular mechanisms of IOC explicitly in the context of aging. Research that includes human participants, or that is informed by data of human conditions, is encouraged. However, since all models can provide important mechanistic insight, any animal species may be included. General areas of research could include, but are not limited to, studies on the molecular mechanisms and consequences of the following:
- Changes with age or health status in communication between two or more organ systems.
- Changes in IOC that alter the apparent rate of aging, including, but not limited to, environmental exposures.
- Changes in IOC by interventions that have been shown to lower the apparent rate of aging (i.e, extend lifespan or healthspan), such as pharmaceuticals, diets, and/or exercise.
- Potential of regulating IOC as an anti-aging strategy.
- How age-related changes in neural function alter peripheral organ physiology/function.
- Age-related changes in the activity/function of tissue-resident immune cells in the context of mediating IOC.
Funding Information
- Award Ceiling: $400,000
- The maximum project period is 5 years.
Eligibility Criteria
- Higher Education Institutions
- Public/State Controlled Institutions of Higher Education
- Private Institutions of Higher Education
- The following types of Higher Education Institutions are always encouraged to apply for NIH support as Public or Private Institutions of Higher Education:
- Nonprofits Other Than Institutions of Higher Education
- Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Higher Education)
- Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education)
- For-Profit Organizations
- Small Businesses
- For-Profit Organizations (Other than Small Businesses)
- Local Governments
- State Governments
- County Governments
- City or Township Governments
- Special District Governments
- Indian/Native American Tribal Governments (Federally Recognized)
- Indian/Native American Tribal Governments (Other than Federally Recognized)
- Federal Government
- Eligible Agencies of the Federal Government
- U.S. Territory or Possession
- Other
- Independent School Districts
- Public Housing Authorities/Indian Housing Authorities
- Native American Tribal Organizations (other than Federally recognized tribal governments)
- Faith-based or Community-based Organizations
- Regional Organizations.
For more information, visit Grants.gov.
