The National Institutes of Health (NIH) supports investigations with a minimum of two Alzheimer’s Disease-Related Dementias (ADRD) co-pathologies (e.g., tau, alpha-synuclein, TDP-43, TMEM106B, vascular), with or without risk factors and co-morbidities, in the same model system to identify interactions and cellular and molecular mechanisms to determine how, whether, and when these interactive multi-pathology mechanisms drive worsening pathophysiology and clinical phenotypic outcomes, such as cognitive, behavioral, or functional impairment.
Donor Name: National Institutes of Health (NIH)
State: All States
County: All Counties
U.S. Territories: American Samoa, Commonwealth of Northern Mariana Islands, Commonwealth of Puerto Rico, Guam, U.S. Virgin Islands
Type of Grant: Grant
Deadline: 09/04/2023
Size of the Grant: $500,000
Grant Duration: 5 years
Details:
The Goal of National Plan to Address Alzheimer’s Disease is to prevent and effectively treat Alzheimer’s disease (AD) and Alzheimer’s Disease Related Dementias (ADRD) by 2025. ADRD are defined as Frontotemporal dementia (FTD), Vascular Contributions to Cognitive Impairment and Dementia (VCID), Lewy Body Dementias (LBD) and Multiple Etiology Dementias (MED). Starting in 2012, the National Institute on Aging (NIA) and the National Institute of Neurological Disorders and Stroke (NINDS) have held research summits to assess the needs and set AD/ADRD research implementation milestones. The NINDS ADRD Summit in 2022 resulted in ADRD research priorities for advancing the state-of-the-science toward meeting Goal 1 of the National Plan. This NOFO is responsive to several high priority milestones established at the 2022 ADRD Summit, including advancing basic research on the common and interacting mechanisms and risk factors of multiple etiology cognitive impairment and dementia in diverse populations, and identifying life course and multi-level mechanisms of and pathways to AD/ADRD.
This NOFO accepts studies using various model systems, including animal models, animal/human cellular systems, organoids, postmortem tissue and other biospecimens, etc. to support investigations with a minimum of two ADRD co-pathologies (e.g., tau, alpha-synuclein, TDP-43, TMEM106B, vascular), with or without risk factors and co-morbidities, in the same model system to identify interactions and cellular and molecular mechanisms to determine how, whether, and when these interactive multi-pathology mechanisms drive worsening pathophysiology and clinical phenotypic outcomes, such as cognitive, behavioral, or functional impairment.
Funding Information
- NINDS intends to commit a total budget of up to $3,750,000 per year to fund up to five awards for up to five years, contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.
- Application budgets are limited to no more than $500,000 direct costs per year and should reflect the actual needs of the proposed project.
Project Period
The scope of the proposed project should determine the project period. The maximum project period is five years.
Eligibility Criteria
Higher Education Institutions
- Public/State Controlled Institutions of Higher Education
- Private Institutions of Higher Education
The following types of Higher Education Institutions are always encouraged to apply for NIH support as Public or Private Institutions of Higher Education:
- Hispanic-serving Institutions
- Historically Black Colleges and Universities (HBCUs)
- Tribally Controlled Colleges and Universities (TCCUs)
- Alaska Native and Native Hawaiian Serving Institutions
- Asian American Native American Pacific Islander Serving Institutions (AANAPISIs)
Nonprofits Other Than Institutions of Higher Education
- Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Higher Education)
- Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education)
For-Profit Organizations
- Small Businesses
- For-Profit Organizations (Other than Small Businesses)
Local Governments
- State Governments
- County Governments
- City or Township Governments
- Special District Governments
- Indian/Native American Tribal Governments (Federally Recognized)
- Indian/Native American Tribal Governments (Other than Federally Recognized)
Federal Government
- Eligible Agencies of the Federal Government
- U.S. Territory or Possession
Other
- Independent School Districts
- Public Housing Authorities/Indian Housing Authorities
- Native American Tribal Organizations (other than Federally recognized tribal governments)
- Faith-based or Community-based Organizations
- Regional Organizations
Foreign Institutions
- Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply.
- Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.
- Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
For more information, visit Grants.gov.
