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You are here: Home / Grant Size / $1 Million to $50 Million / Emergency Award: RADx-UP D and I Research on COVID-19 Testing Interventions among Underserved and Vulnerable Populations

Emergency Award: RADx-UP D and I Research on COVID-19 Testing Interventions among Underserved and Vulnerable Populations

Dated: May 4, 2023

The National Institutes of Health (NIH) is accepting applications to support dissemination and implementation (D&I) research focused on increasing access to and uptake of coronavirus disease 2019 (COVID-19) testing interventions – with the goal of reducing COVID-19 disparities and promoting health equity among underserved and vulnerable populations.

Donor Name: National Institutes of Health (NIH)

State: All States

County: All Counties

U.S. Territories: American Samoa, Commonwealth of Northern Mariana Islands, Commonwealth of Puerto Rico, Guam, U.S. Virgin Islands

Type of Grant: Grant

Deadline: 06/09/2023

Size of the Grant: $1.8M

Grant Duration: 3 years

Details:

This NOFO will support D&I research on how evidence-based practices, interventions, and policies are effectively translated to and used in real-world settings. Projects may evaluate the adoption, adaptation, integration, scale-up, and sustainability of evidence-based interventions, or seek to understand the “de-implementation” of practices that are ineffective, low-value, or inequitable. Interventions developed through the Rapid Acceleration of Diagnostics – Underserved Populations (RADx®-UP) initiative are encouraged, but not required.

The RADx®-UP initiative seeks to address COVID-19 morbidity and mortality disparities among underserved and vulnerable populations with disproportionate rates of SARS-CoV-2 and/or undue COVID-19 burden by understanding strategies and interventions to increase testing access, acceptability, and uptake. To date, more than 135 projects are engaging participants in all US states as well as American Samoa, the District of Columbia, Guam, the Northern Mariana Islands, Puerto Rico, and the US Virgin Islands.

Goals

  • This NOFO invites applications for D&I research project grants (R01s) to 1) develop and test D&I strategies for the equitable and effective adoption, adaptation, integration, scale-up, and sustainability of evidence-based COVID-19 testing interventions among underserved and vulnerable populations, or 2) understand circumstances that create a need to stop, reduce and/or replace (“de-implement”) the use of interventions related to COVID-19 testing that are ineffective, low-value or in-equitable, and identify optimal strategies to successfully “de-implement” such interventions.
  • D&I of COVID-19 testing interventions developed through RADx-UP are encouraged, but not required.
  • This NOFO will support rigorous study designs and methods including (but not limited to) observational, experimental, quasi-experimental, observational, hybrid effectiveness-implementation, configurational comparative, and simulation modeling that produce evidence on relevant outcomes (e.g., adoption, fidelity, penetration, sustainability), costs, and/or unanticipated consequences of D&I efforts. The goal is to conduct D&I studies utilizing research designs that are rigorous and measures that are contextually and culturally appropriate.
  • This NOFO encourages studies to test models, theories, and conceptual frameworks of the implementation process that move away from an exclusively “top-down” or reductionist approach to a greater emphasis on the resources of local care settings and the needs of multiple stakeholders, including approaches such as systems science, team science, community engaged research, participatory action research, citizen science, and related approaches that engage stakeholders and end-users throughout the research process.

Research Objectives

The D&I research topics and questions of interest include, but are not limited to, the following areas:

  • What culturally and community specific D&I strategies can enhance the reach, adoption, effectiveness, integration and/or maintenance of COVID-19 testing interventions, including testing linked to active treatment of an infection (i.e., “test to treat” paradigms)?
  • How can D&I strategies for implementing evidence-based COVID-19 testing interventions be designed to optimally overcome barriers associated with structural racism and discrimination?
  • What are effective strategies to disseminate and implement multiple evidence-based COVID-19 testing interventions within community or clinical settings (including community clinics, Federally Qualified Health Centers [FQHCs], and primary care clinics) to meet the needs of underserved and vulnerable patients and diverse systems of care?
  • What are the critical barriers and facilitators that contribute to the adoption and sustainability of evidence-based COVID-19 testing interventions in public health, clinical practice, and school/academic environments, particularly in the context of evolving COVID-19 trajectories, experiences, perceptions, and policies?
  • What are the key determinants for understanding circumstances that create a need to stop or reduce (“de-implement”) the use of practices related to COVID-19 testing that are ineffective, low-value or in-equitable?
  • What are optimal context-specific strategies and considerations for successfully disseminating evidence relating to the need for de-implementation of practices related to COVID-19 testing that are ineffective low-value or in-equitable?
  • What are effective efforts to change behavior at multiple levels (individual, clinician, system, or policy level) related to COVID-19 testing and prevention to reduce health disparities and improve quality of care?

Funding Information

Application budgets are limited to $1.8M in direct costs for the entire project.

Project Period

The maximum project period is three years.

Eligibility Criteria

Higher Education Institutions

  • Public/State Controlled Institutions of Higher Education
  • Private Institutions of Higher Education

The following types of Higher Education Institutions are always encouraged to apply for NIH support as Public or Private Institutions of Higher Education:

  • Hispanic-serving Institutions
  • Historically Black Colleges and Universities (HBCUs)
  • Tribally Controlled Colleges and Universities (TCCUs)
  • Alaska Native and Native Hawaiian Serving Institutions
  • Asian American Native American Pacific Islander Serving Institutions (AANAPISIs)

Nonprofits Other Than Institutions of Higher Education

  • Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Higher Education)
  • Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education)

For-Profit Organizations

  • Small Businesses
  • For-Profit Organizations (Other than Small Businesses)

Local Governments

  • State Governments
  • County Governments
  • City or Township Governments
  • Special District Governments
  • Indian/Native American Tribal Governments (Federally Recognized)
  • Indian/Native American Tribal Governments (Other than Federally Recognized)

Federal Government

  • Eligible Agencies of the Federal Government
  • U.S. Territory or Possession

Other

  • Independent School Districts
  • Public Housing Authorities/Indian Housing Authorities
  • Native American Tribal Organizations (other than Federally recognized tribal governments)
  • Faith-based or Community-based Organizations
  • Regional Organizations

Foreign Institutions

  • Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply.
  • Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.
  • Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

For more information, visit Grants.gov.

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