The INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Project seeks to improve health and quality-of-life for individuals with Down syndrome (DS). This Funding Opportunity Announcement (FOA) is intended to solicit requests for research to foster the development of and expand the access to animal models for DS-related research and related biological materials and information that would advance preclinical and basic science studies related to DS.
Donor Name: National Institutes of Health
State: All States
County: All Counties
Territory: American Samoa, Commonwealth of Puerto Rico, Commonwealth of the Northern Mariana Islands, Guam, and U.S. Virgin Islands
Type of Grant: Grant
Deadline: 05/26/2025
Size of the Grant: $1.5 million
Grant Duration: 4 years
Details:
The INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Project encourages grant applications aimed at developing, characterizing, or improving animal models and related biological materials for Down syndrome (DS) related research and improving access to information about or from the use of animal models for DS research. The animal models and related biological materials developed must have utility in targeted or basic science studies in areas highly relevant to DS. With this funding opportunity announcement, the INCLUDE Project encourages, but is not limited to, projects focusing on development of various animal models, genetic resources, atlases at a single cell or subcellular level, advanced informatics technologies including artificial intelligence (AI) or machine learning (ML), and integration of multiple animal models and technology platforms for enhancing rigor and reproducibility of preclinical DS research.
This FOA is one of several NIH-wide research initiatives created in response to Fiscal Year 2018, 2019, and 2020 Omnibus Appropriations Reports, which encourage NIH to expand its current efforts on DS and common co-occurring conditions also seen in the general population, while increasing the pipeline of DS investigators. Together, the initiatives are called the INCLUDE Project (INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE). The INCLUDE Project has three components:
- Component 1: Targeted high risk – high reward basic science studies in areas highly relevant to Down syndrome
- Component 2: Assembly of a large cohort of individuals with Down syndrome across the lifespan to perform deep phenotyping and study co-existing conditions
- Component 3: Inclusive clinical trials of existing and future treatments and interventions for co-occurring conditions in individuals with Down syndrome.
Funding Information
- The National Institutes of Health (NIH) intends to commit $1.5 million per fiscal year in FY2023-2026 to fund at least two awards per fiscal year.
- The duration of the proposed project may not exceed four years.
Eligibility Criteria
- Higher Education Institutions
- Public/State Controlled Institutions of Higher Education
- Private Institutions of Higher Education
- The following types of Higher Education Institutions are always encouraged to apply for NIH support as Public or Private Institutions of Higher Education:
- Nonprofits Other Than Institutions of Higher Education
- Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Higher Education)
- Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education)
- For-Profit Organizations
- Small Businesses
- For-Profit Organizations (Other than Small Businesses)
- Local Governments
- State Governments
- County Governments
- City or Township Governments
- Special District Governments
- Indian/Native American Tribal Governments (Federally Recognized)
- Indian/Native American Tribal Governments (Other than Federally Recognized)
- Federal Governments
- Eligible Agencies of the Federal Government
- U.S. Territory or Possession.
For more information, visit Grants.gov.
