This Funding Opportunity Announcement (FOA) solicits applications that propose to conduct time-sensitive ancillary studies related to the NIAMS mission in conjunction with privately or publicly funded, active, ongoing clinical projects (parent projects).
Donor Name: National Institutes of Health
State: All States
County: All Counties
Territory: American Samoa, Commonwealth of Puerto Rico, Commonwealth of the Northern Mariana Islands, Guam, and U.S. Virgin Islands
Type of Grant: Grant
Deadline: 12/05/2025
Size of the Grant: $400,000
Grant Duration: 2 years
Details:
The parent project can be an interventional clinical trial, or a clinical study such as an observational study, or a disease-specific repository that will be actively collecting patient samples or clinical data. The parent project(s) should provide a cohort of well-characterized patients, infrastructure, data, and biological samples for the ancillary study. Applications submitted in response to this FOA will undergo an accelerated review and award process. The objective of this FOA is to provide a flexible mechanism to leverage currently funded resources and maximize the return on existing investments in parent projects. Successful ancillary studies will enhance the scientific content and value of the parent projects, improve the research community’s understanding of a disease or organ system in the NIAMS portfolio, and thus may identify novel targets for diagnosis, treatment, and prevention of disease.
The objectives of the parent study need not relate to the NIAMS mission, so long as the parent study provides an appropriate venue for the proposed ancillary study.
Ancillary studies are encouraged to be mechanistic in nature but can expand to non-mechanistic research. Examples of research may include but are not limited to those listed below under this FOA. These are only examples and are not meant to be all inclusive:
- Novel cellular, molecular, genetic and/or epigenetic mechanisms of disease.
- Novel cellular and/or molecular fingerprints that reflect the disease onset and/or progression.
- Novel pathogenic signaling pathways.
- Novel cellular and molecular disease/drug target identification.
- Underlying mechanism of action of a drug or intervention.
- Underlying environmental, behavior, or other risk factors that are responsible for differences in disease onset and progression.
- Mechanisms that explain disease comorbidity or functional impairment and pathophysiology of the disease.
- Underlying etiology of a subset of a disease.
- Discovery and validation of biomarkers.
- Outcome measures that reflect or relate to the disease activity or structural/functional tissue changes or action, toxicity, and activity of the therapeutic agent and its effects.
- Mechanism of sex differences in disease onset and progression.
- Mechanisms of pain or pain perception in diseases.
- Development and validation of novel methodology to advance the parent study design or analysis of data.
Funding Information
- Direct costs are limited to $400,000 over a two-year period, with no more than $250,000 in direct costs in any single year.
- The maximum project period is two years.
Eligibility Criteria
- Higher Education Institutions
- Public/State Controlled Institutions of Higher Education
- Private Institutions of Higher Education
- The following types of Higher Education Institutions are always encouraged to apply for NIH support as Public or Private Institutions of Higher Education:
- Nonprofits Other Than Institutions of Higher Education
- Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Higher Education)
- Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education)
- For-Profit Organizations
- Small Businesses
- For-Profit Organizations (Other than Small Businesses)
- Local Governments
- State Governments
- County Governments
- City or Township Governments
- Special District Governments
- Indian/Native American Tribal Governments (Federally Recognized)
- Indian/Native American Tribal Governments (Other than Federally Recognized)
- Federal Governments
- Eligible Agencies of the Federal Government
- U.S. Territory or Possession
- Other
- Independent School Districts
- Public Housing Authorities/Indian Housing Authorities
- Native American Tribal Organizations (other than Federally recognized tribal governments)
- Faith-based or Community-based Organizations
- Regional Organizations.
For more information, visit Grants.gov.
