The National Institutes of Health is seeking applications to provide salary and research support to investigators who are within ten years of completing their terminal professional degree or residency training.
Donor Name: National Institutes of Health
State: All States
County: All Counties
Territory: Commonwealth of Puerto Rico, Guam, U.S. Virgin Islands, American Samoa, and Commonwealth of Northern Mariana Islands
Type of Grant: Grant
Deadline: 08/07/2023
Grant Duration: 3 years
Details:
The overall goal of the NIH Research Career Development program is to help ensure that a diverse pool of highly trained scientists is available in appropriate scientific disciplines to address the Nation’s biomedical, behavioral, and clinical research needs. NIH Institutes and Centers (ICs) support a variety of mentored and non-mentored career development award programs designed to foster the transition of new investigators to research independence and to support established investigators in achieving specific objectives. Candidates should review the different career development (K) award programs to determine the best program to support their goals.
The objective of the NIH Mentored Research Scientist Development Award (K01) is to provide salary and research support for a sustained period of “protected time” (3-5 years) for intensive research career development, under the guidance of an experienced mentor, or sponsor in the biomedical, behavioral or clinical sciences leading to research independence. The expectation is that, through this sustained period of research career development and training, recipients will launch independent research careers and become competitive for new research project grant (e.g., R01) funding.
The purpose of this NIH Mentored Research Scientist Development Award (K01) is to provide salary and research support to investigators who are within ten years of completing their terminal professional degree or residency training and who have at least two years of postdoctoral training or equivalent. For this NOFO, research and mentorship must be focused on HIV/AIDS studies using nonhuman primates (NHPs) as preclinical models. These awards will provide three years of support for intensive research career development under the guidance of an experienced mentorship team, with expertise both in the use of NHPs as preclinical models and in the translation of results from NHP models to humans. The expectation is that through this sustained period of research career development, awardees will launch independent research careers and become competitive for new research project grant (e.g., R01) funding.
Preclinical studies using NHPs are essential for development of effective HIV/AIDS treatment and prevention. Further, the FY 2021-2025 NIH Strategic Plan for HIV and HIV-Related Research identifies several high-priority areas for HIV/AIDS treatment and prevention for which NHP models are highly relevant. These topics include, but are not limited to:
- Vaccines, vaccine adjuvants and other novel antiretroviral therapy-free approaches to viral remission or eradication directed towards Simian Immunodeficiency Virus/Simian-Human Immunodeficiency Virus (SIV/SHIV) at various stages of the lifespan, including neonates and infants;
- Non-vaccine prevention, such as oral pre-exposure prophylaxis neutralizing monoclonal antibodies, or mucosal microbicides;
- Antiretrovirals, more effective and safer combination antiretroviral treatment (cART), or combined drug/immunotherapeutic approaches;
- Identification, characterization and therapeutic targeting of anatomic sanctuary sites serving as latent reservoirs of the virus during antiretroviral treatment (ART);
- Identification of biomarkers predicting viral remission or reactivation/rebound of latent virus;
- Impact of co-morbidities and co-infections on SIV/SHIV acquisition/transmission, progression to AIDS, and/or interactions with treatment modality;
- Imaging and monitoring/tracking SIV/SHIV, antibodies, and immune cells.
Research Objectives
- In addition to ORIP’s interests, described above, other participating Institutes are interested in fostering career development in the research areas indicated below.
- The National Institute of Allergy and Infectious Diseases (NIAID) is interested in research applications focused on:
- Fundamental research on SIV/SHIV persistence
- Innovative vaccine design beyond maximizing immunogenicity
- Dynamics of intact proviral HIV reservoirs
- Identification and characterization of the sources of viral rebound
- Long-acting therapies and antivirals with novel mechanisms of action
- Development and testing of curative strategies for eradicating or controlling residual/rebounding virus.
Grant Period
The total project period may not exceed 3 years.
Eligibility Criteria
- Higher Education Institutions
- Public/State Controlled Institutions of Higher Education
- Private Institutions of Higher Education
- The following types of Higher Education Institutions are always encouraged to apply for NIH support as Public or Private Institutions of Higher Education:
- Nonprofits Other Than Institutions of Higher Education
- Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Higher Education)
- Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education)
- Governments
- State Governments
- County Governments
- City or Township Governments
- Special District Governments
- Indian/Native American Tribal Governments (Federally Recognized)
- Indian/Native American Tribal Governments (Other than Federally Recognized)
For more information, visit Grants.gov.
