The National Institutes of Health (NIH) is seeking applications for its Resource-Related Research Projects for Development of Models and Related Materials for Studying Human Health and Diseases Program.
Donor Name: National Institutes of Health (NIH)
State: All States
County: All Counties
Territory: Commonwealth of Puerto Rico, Guam, U.S. Virgin Islands, American Samoa, Commonwealth of the Northern Mariana Islands
Type of Grant: Grant
Deadline: 12/27/2025
Size of the Grant: $100,000 to $500,000
Grant Duration: 4 Years
Details:
The Office of Research Infrastructure Programs (ORIP) encourages grant applications aimed at developing, characterizing, or improving research models of human health and diseases; developing biology based new approach methodologies (NAMs) applicable to human health and diseases; or improving access to information about or generated from the use of models of human disease. The models, including NAMs, and related biological materials developed must be broadly applicable to the scientific interests of two or more NIH Institutes or Centers (ICs) and must evaluate diseases and processes that impact multiple organ systems in order to align with the ORIP’s NIH-wide mission and programs. Applications must describe the need for and the potential impact of the proposed resources on the research community across a range of scientific disciplines supported by multiple NIH ICs. Applications to develop models that relate strictly to a specific disease or a select area of research or that do not have a broad impact on the NIH-wide research community will not be accepted. Projects that predominantly address the research interests of one NIH IC but are only peripherally related to the research interests of other ICs will also not be accepted, if submitted in response to this notice of funding opportunity (NOFO).
The Office of Research Infrastructure Programs (ORIP) is a program office in the Division of Program Coordination, Planning, and Strategic Initiatives (DPCPSI) dedicated to supporting research infrastructure and related research resource programs. ORIP consists of the Division of Comparative Medicine (DCM) and the Division of Construction and Instruments (DCI).
ORIP’s intent with this NOFO is to support resource-related research projects that are aimed at developing and characterizing new human health- and disease-based resources, improving existing resources, or acquiring deep understanding of a model system to improve the utilization, accessibility, and translational value of experimental research models to the research community. The NIH-wide mission of ORIP is to support all NIH ICs that fund basic, preclinical, and translational research by strengthening their existing programs, developing research resources, advancing areas of emerging science, and developing new initiatives to move biomedical research forward. Therefore, proposed studies, models, technologies, methodologies, and biological materials must be applicable to two or more NIH ICs and must explore multiple organ systems or evaluate diseases and processes that impact multiple organ systems.
An application under this NOFO may be predominantly research based if that research potentially leads to the development of tools or resources that will have a broad impact on the NIH-wide biomedical research community. An application also may be aimed at final development or enhancement of existing resources.
Applications responding to this NOFO should:
- Demonstrate the need for the proposed resources or technologies/tools within broad biomedical research communities and the relevance of the resources and technologies/tools to a range of scientific disciplines.
- Address the impact, benefit, utilization, distribution, and accessibility of the proposed resources and technologies/tools to broad biomedical research areas supported by multiple NIH ICs.
- Describe plans to track potential impact of the proposed resources and technologies/tools.
- Describe potential sources of support for the resources and technologies/tools as well as plans to ensure the continued availability of the resources and technologies/tools to the research community after the ORIP-supported grant ends, such as plans to deposit the resources to stock centers or databases accessible to the research community.
- Include a replication and validation plan for proposed models or related resources to be developed.
Funding Information
Applicants requesting $500,000 or more in direct costs in any year.
Project Period
The duration of the proposed project may not exceed four years.
Eligibility Criteria
Higher Education Institutions – Includes all types
- Public/State Controlled Institutions of Higher Education
- Private Institutions of Higher Education
Nonprofits Other Than Institutions of Higher Education
- Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Higher Education)
- Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education)
For-Profit Organizations
- Small Businesses
- For-Profit Organizations (Other than Small Businesses)
Local Governments
- State Governments
- County Governments
- City or Township Governments
- Indian/Native American Tribal Governments (Federally Recognized)
- Indian/Native American Tribal Governments (Other than Federally Recognized)
Federal Governments
- Eligible Agencies of the Federal Government
- U.S. Territory or Possession
Foreign Organizations/Foreign Collaborations
- Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.
- Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.
- Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
For more information, visit Grants.gov.
