The National Institutes of Health (NIH) is seeking applications for its Phased Multi-Site Clinical Trial: Testing Prevention of Cardiovascular Disease in Young Adults With High Lifetime Risk Using Surrogate Outcomes – Data Coordinating Center.
Donor Name: National Institutes of Health (NIH)
State: All States
County: All Counties
Type of Grant: Grant
Deadline: 10/28/2024
Size of the Grant: More than $1 million
Grant Duration: 5-10 Years
Details:
The goal of this Notice of Funding Opportunity (NOFO) is to support a clinical trial which will test intervention(s) to reduce the progression of coronary atherosclerosis among young adults who are at low or borderline 10-year risk (<7.5%) for their first atherosclerotic cardiovascular disease (ASCVD) event, yet at high lifetime risk of developing cardiovascular disease (CVD). For the purpose of this NOFO, “young adults” is defined as less than or equal to 50 years for men, and given the lower rate of coronary atherosclerosis before menopause for women compared to men, it may be reasonable to use an expanded inclusion criteria to include women older than age 50.
This opportunity will support a two component primary prevention clinical trial that will first, efficiently screen the appropriate population eligible for the intervention, and second, determine which intervention(s) are most efficacious at reducing the onset or slowing the progression of subclinical coronary atherosclerosis. Trial participants who are identified as meeting the subclinical coronary atherosclerosis criteria for enrollment in the screening component will be immediately enrolled in the intervention, even though component one recruitment continues until the trial is completely enrolled.
Purpose
NHLBI seeks to stimulate clinical trial research that efficiently identifies young adults with subclinical coronary atherosclerosis and determines whether early treatment significantly reduces the progression of coronary atherosclerosis. Since women have less coronary artery atherosclerosis before menopause, inclusion of women older than 50 years old may be considered. This NOFO proposes a three-arm clinical trial which is expected to be conducted with a high degree of efficiency, and with streamlined administrative procedures wherever possible.
Funding Information
The NHLBI intends to commit total costs of up to $972,356 in Fiscal Year (FY) 2025; up to $1,750,980 in FY 2026; up to $1,483,790 in FY 2027; up to $1,483,328 in FY 2028; up to $1,145,144 in FY 2029; up to $1,145,760 in FY 2030; and up to $698,076 in FY 2031.
Project Period
The period of award is expected to be up to 7 years.
Eligibility Criteria
Higher Education Institutions
- Public/State Controlled Institutions of Higher Education
- Private Institutions of Higher Education
The following types of Higher Education Institutions are always encouraged to apply for NIH support as Public or Private Institutions of Higher Education:
- Hispanic-serving Institutions
- Historically Black Colleges and Universities (HBCUs)
- Tribally Controlled Colleges and Universities (TCCUs)
- Alaska Native and Native Hawaiian Serving Institutions
- Asian American Native American Pacific Islander Serving Institutions (AANAPISIs)
Nonprofits Other Than Institutions of Higher Education
- Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Higher Education)
- Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education)
For-Profit Organizations
- Small Businesses
- For-Profit Organizations (Other than Small Businesses)
Local Governments
- State Governments
- County Governments
- City or Township Governments
- Special District Governments
- Indian/Native American Tribal Governments (Federally Recognized)
- Indian/Native American Tribal Governments (Other than Federally Recognized)
Federal Governments
- Eligible Agencies of the Federal Government
- U.S. Territory or Possession
Other
- Independent School Districts
- Public Housing Authorities/Indian Housing Authorities
- Native American Tribal Organizations (other than Federally recognized tribal governments)
- Faith-based or Community-based Organizations
- Regional Organizations
Foreign Organizations
- Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.
- Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.
- Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
For more information, visit Grants.gov.
