NIH: Interventions Testing Program (ITP) Data Coordinating Center

This Funding Opportunity Announcement (FOA) invites applications utilizing a cooperative agreement (U24) mechanism to implement a Data Coordinating Center (DCC) that will provide data storage, analysis tools, data analyses, and sharing of data generated by the Interventions Testing Program (ITP), and will develop a publicly accessible and interactive website.

Donor Name: National Institutes of Health (NIH)

State: All States

Deadline: 06/19/2023

Size of the Grant: $200,000

Grant Duration: 5 years

Details:

The ITP tests intervention strategies that may delay aging in mammals under standardized conditions. The ITP applies Standard Operating Procedures (SOPs), protocols, and statistical procedures for conducting lifespan studies established over the course of several years. The data generated by the ITP include, but are not limited to, results from compound pilot studies, lifespan data and analyses, geropathology assessments, and molecular phenotypes. The ITP also collects tissues for ancillary studies that are available to the research community.

The goals of the ITP DCC include the following:

• Maintain current information on experimental designs, protocols, and SOPs. Data coordination among the three Centers of the ITP consortium involves maintaining and sharing documentation of statistical procedures and approaches used in lifespan studies during the past and current years of the ITP. The analytical methods developed over that time frame by the ITP include blinding and randomization, power analysis, sample size estimates based on anticipated variability in primary or secondary outcome(s) of interest, potential inclusion of interim analyses and quality control for data collection in lifespan studies. The DCC will coordinate with the three ITP Centers to collect detailed information about the SOPs, experimental strategy, protocols, and statistical analyses.
• Coordinate data collection and sharing among the three ITP Centers. The DCC will coordinate with ITP investigators for the timely acquisition, quality control, storage, and curation of data generated by the ITP. It will ensure, where needed, compatibility of older data and new data if any change in data format is introduced. Data will include, but will not be limited to, pilot studies of best dose selection for newly tested compounds, lifespan data and analyses, geropathology, pathology, and transcriptomics.
• Coordinate collection of data from ancillary studies conducted using tissues generated by the ITP. This involves maintaining and updating a publicly accessible electronic inventory of samples in the Interventions Biospecimens Repository and collecting and managing data generated using such samples, including, but not limited to, images and -omics. The DCC will provide access to data generated by these studies upon publication.
• Establish a statistical core for independent analysis of data obtained by the ITP. The DCC will contribute with independent statistical data analysis of Stage I and Stage II lifespan studies.
• House and maintain a public-access interactive website and data repository. The public-facing interactive website will provide access to experimental design, protocols, SOPs and analytical tools (e.g., statistical and visualization) as well as curated and summary data from the ITP testing studies (e.g., lifespan, animal vitals, geropathology, pathology, transcriptomics) including data from the pilot studies (e.g., drug stability, bioavailability, best dose selection). All data, including those generated by ancillary studies, will be made publicly available through the website upon publication.

Funding Information

Direct costs may not exceed $200,000.

Project Period

The maximum project period is 5 years.

Eligibility Criteria

Higher Education Institutions

• Public/State Controlled Institutions of Higher Education
• Private Institutions of Higher Education

The following types of Higher Education Institutions are always encouraged to apply for NIH support as Public or Private Institutions of Higher Education:

• Hispanic-serving Institutions
• Historically Black Colleges and Universities (HBCUs)
• Tribally Controlled Colleges and Universities (TCCUs)
• Alaska Native and Native Hawaiian Serving Institutions
• Asian American Native American Pacific Islander Serving Institutions (AANAPISIs)

Nonprofits Other Than Institutions of Higher Education

• Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Higher Education)
• Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education)

For-Profit Organizations

• Small Businesses
• For-Profit Organizations (Other than Small Businesses)

Local Governments

• State Governments
• County Governments
• City or Township Governments
• Special District Governments
• Indian/Native American Tribal Governments (Federally Recognized)
• Indian/Native American Tribal Governments (Other than Federally Recognized)

Federal Government

• Eligible Agencies of the Federal Government
• U.S. Territory or Possession

Other

• Independent School Districts
• Public Housing Authorities/Indian Housing Authorities
• Native American Tribal Organizations (other than Federally recognized tribal governments)
• Faith-based or Community-based Organizations
• Regional Organizations

Foreign Institutions

• Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply.
• Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.
• Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

For more information, visit Grants.gov.