The National Institutes of Health is accepting grant applications to support research on the effects of HIV and addictive substances, acting independently or synergistically on blood brain barrier (BBB) structure and function and the involvement of these effects in HIV associated neuropathology.
Donor Name: National Institutes of Health
State: All States
County: All Counties
Type of Grant: Grant
Deadline (mm/dd/yyyy): 07/11/2022
Grant Size: $2,000,000
Grant Duration: 5 years
Details:
The blood brain barrier (BBB) is a target of both the HIV virus and substances of abuse. It is a site of entry for HIV infected monocytes and macrophages that can traverse the BBB either paracellularly or transcellularly. HIV viral proteins can also attack astrocytes and tight junctions of BBB directly and compromise its integrity, resulting in the crossing of the virus, as well as abused substances, into the brain. Meanwhile, many substances of abuse cause BBB dysfunction. Because BBB integrity regulates both substances and virus levels in the brain, it is critical to establish the mechanisms by which HIV infection, in combination with substances of abuse, affect BBB function and integrity and their consequences. The purpose of this initiative is to support innovative research that elucidates the roles of HIV and addictive substances in the pathology of BBB. This FOA encourages studies to expand the current understanding of the basic molecular mechanisms underlying virus mobilization across BBB, and pathology of BBB in HIV infection and substance use disorders (SUD). In addition, studies are encouraged to develop and test novel BBB models to assess the delivery of pharmacological and immunotherapies to treat HIV infection and SUD, and to suppress HIV replication in CNS.
Funding Information
- NIDA intends to commit $2,000,000 in FY 2023 to fund 3 to 5 awards.
- The project period is limited to 5 years.
Eligibility Criteria
- Native American tribal governments (Federally recognized)
- Public housing authorities/Indian housing authorities
- Independent school districts
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- City or township governments
- Native American tribal organizations (other than Federally recognized tribal governments)
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- For profit organizations other than small businesses
- Special district governments
- County governments
- State governments
- Private institutions of higher education
- Public and State controlled institutions of higher education
- Small businesses
For more information, visit Grants.gov.
