The National Institutes of Health is inviting applications to establish a new population-based cohort study to address key population research gaps in the health of Asian Americans (AsA), Native Hawaiians, and Pacific Islanders (NHPI).
Donor Name: National Institutes of Health
State: All States
County: All Counties
Territory: Commonwealth of Puerto Rico, the U.S. Virgin Islands, Guam, American Samoa, the Commonwealth of the Northern Mariana Islands
Type of Grant: Grant
Deadline: 10/13/2022
Size of the Grant: up to $373,000
Grant Duration: 7 years
Details:
This epidemiological cohort study will enable the enrollment, initial examination, and follow-up activities of a cohort of participants from multiple immigrant generations of ancestral Asians living in the United States, as well as Native Hawaiians, and Pacific Islanders. Specifically, this initiative will utilize a “populomics” perspective, i.e., examination of health influences across multiple levels (biological, lifestyle/behavioral, environmental, sociocultural) using multi-disciplinary methods to investigate the web of influences impacting the health of AsA-NHPI subpopulations. The estimated number of total participants from all awards is about 10,000. This FOA uses a bi-phasic, milestone-driven, cooperative agreement mechanism (UG3/UH3).
Research Scope/Objectives
Through this initiative, NHLBI will take the lead in establishing a new epidemiological cohort study to systematically investigate factors of risk and resilience and other potential factors impacting the health of AsA-NHPI subpopulations. The estimated number of target participants from all awards is approximately 10,000, which will include 4 to 5 major subpopulations of AsA-NHPI. To improve our understanding of human genetic variation, 25% of the total participant population should include AsA-NHPI subpopulations who are among the most understudied in biomedical research. A multi-generational design will be encouraged to further the understanding of how generation and nativity influence risk and health outcomes. An examination that will systematically collect standardized, high-quality phenotypic data from participants will be a key feature and will enable the opportunity to pursue multiple research hypotheses within a single research design.
The sampling design will support two analytical objectives:
- to estimate the prevalence, mean values and distribution of key health and risk factors, with sufficient sample size to stratify by place of origin of major AsA-NHPI subpopulations and other relevant demographic characteristics that are clearly defined, consistently used and transparently presented (e.g., sex, gender, education, occupation, religiosity, income, self-identified race and ethnicity, etc.);
- to evaluate relationships among baseline risk factors, and relationships of risk factors with health outcomes. Representative samples of participants will be drawn from census tracts in these defined communities and recruited from households using strategies that maximize participation rates, and minimize nonresponse and attrition during follow-up.
Specific Areas of Research
Core questions that are expected to be addressed through the baseline exam include the following:
- How does cardiovascular and lung health in first- and subsequent-generation immigrants differ from comparable cohorts in their countries of origin?
- How do generational and neighborhood exposures impact health outcomes, including sleep quality, mental health, cardiopulmonary, and cognition among AsA-NHPI subpopulations?
- What is the interrelationship between acculturation, discrimination, neighborhood factors, social networks and kinship structures and how do these factors intersect to impact health outcomes?
- What is the relationship between sociocultural, environmental, behavioral, clinical and/or genetic risk factors with metabolic disorders (e.g., glucose intolerance, dyslipidemia) in AsA-NHPI subpopulations?
- What are the health effects of tobacco and nicotine delivery products across populations and the potential impacts on incidence of pulmonary disease and cardiovascular diseases?
- Why is there a need to develop and validate acculturation instruments for AsA-NHPI subpopulations that include items beyond those that are language-based?
- How do protective factors, such as resilience or social support, contribute to health in AsA-NHPI subpopulations, including how such protective factors may differ across immigrant groups and/or generations?
- What is the prevalence and incidence of neurological disease (e.g., stroke, dementia, cognitive impairment, multiple sclerosis, epilepsy, traumatic brain injury, pain syndromes, etc.) in the AsA-NHPI subpopulations?
- What are the independent and combined contributions of genetics and other risk factors (e.g., clinical, family history, environmental, social determinants of health) to the incidence of diseases most severely impacting AsA-NHPI?
Funding Information
- The budget for each application may not exceed direct costs of up to $373,000 in Fiscal Year (FY) 2023, up to $390,000 in FY2024, up to $406,000 per year in FYs 2025 through 2027, and up to $341,000 per year in FY2028 and FY2029.
- The maximum period of the combined UG3 and UH3 phases is 7 years, with up to 2 years for the UG3 phase, and up to 5 years for the UH3 phase.
Eligibility Criteria
- Higher Education Institutions
- Public/State Controlled Institutions of Higher Education
- Private Institutions of Higher Education
- The following types of Higher Education Institutions are always encouraged to apply for NIH support as Public or Private Institutions of Higher Education:
- Nonprofits Other Than Institutions of Higher Education
- Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Higher Education)
- Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education)
- For-Profit Organizations
- Small Businesses
- For-Profit Organizations (Other than Small Businesses)
- Local Governments
- State Governments
- County Governments
- City or Township Governments
- Special District Governments
- Indian/Native American Tribal Governments (Federally Recognized)
- Indian/Native American Tribal Governments (Other than Federally Recognized)
- Federal Government
- Eligible Agencies of the Federal Government
- U.S. Territory or Possession
- Other
- Independent School Districts
- Public Housing Authorities/Indian Housing Authorities
- Native American Tribal Organizations (other than Federally recognized tribal governments)
- Faith-based or Community-based Organizations
- Regional Organizations.
For more information, visit Grant.gov.
