This Request for Applications (RFA) solicits applications for innovative research projects in cancer systems biology.
Donor Name: Cancer Prevention and Research Institute of Texas
State: Texas
County: All Counties
Type of Grant: Grant
Deadline: 08/06/2022
Size of the Grant: $400,000
Grant Duration: 3 years
Details:
Academic Research Program Priorities
The Texas Legislature has charged the CPRIT Oversight Committee with establishing program priorities on an annual basis. These priorities are intended to provide transparency with regard to how the Oversight Committee directs the orientation of the agency’s funding portfolio.
Established Principles:
- Scientific excellence and impact on cancer
- Increasing the life sciences infrastructure
- Achieving health equity and reducing cancer disparities.
The program priorities for academic research adopted by the Oversight Committee include funding projects that address or utilize the following:
- Recruitment of outstanding cancer researchers to Texas
- Investment in core facilities
- A broad range of innovative, investigator-initiated research projects
- Implementation research to accelerate the adoption and deployment of evidence-based prevention and screening interventions
- Computational biology and analytic methods
- Childhood cancers
- Hepatocellular cancer
- Expanding access to innovative clinical trials
Examples of projects responsive to this RFA include, but are not limited to, scientific proposals addressing the following:
- Developing integrated models of genetic/epigenetic, chemical, cytoplasmic/network, microenvironment, and structural features across space and time scales to understand the mechanisms of cancer initiation, progression, metastasis, and therapeutic response;
- Characterization of cellular interactions and their impact on local, systemic, and evolving cellular behaviors that underlie cancer processes, such as initiation, progression, and metastasis;
- Delineation of the interactions between tumor and nontumor components, eg, tumorimmune cell interactions, and involvement in mediating the response or resistance to therapy;
- Integration of the biology underlying normal physiological processes, such as development, aging, metabolism, immunity, or chronic inflammation, to inform cancer development, progression, metastasis, or treatment response;
- Elucidation of the mechanism(s) by which external factors, such as the microbiome, affect tumor biology, including therapeutic response;
- Application of systems biology approaches, eg, network and multiscale modeling, to discover targetable molecular or cellular mechanisms and to test biologically informed therapies, sequences of therapies and combinations of therapies that incorporate variables such as toxicities, dose, and timing; and
- Integration of molecular and cellular oncogenic processes with population-level risk factors, such as obesity or chronic inflammation, or environmental factors that may differentially impact patient populations and influence cancer disparities.
Funding Information
Applicants may request a maximum of $400,000 in total costs per year for up to 3 years.
Eligibility Criteria
- The applicant must be a Texas-based entity. Any not-for-profit institution or organization that conducts research is eligible to apply for funding under this award mechanism.
- A public or private company is not eligible for funding under this award mechanism; these entities must use the appropriate award mechanism(s) under CPRIT’s Product Development Research Program.
- The Principal Investigator (PI) must have a doctoral degree, including MD, PhD, DDS, DMD, DrPH, DO, DVM, or equivalent, and must be a full-time resident of Texas during the time the research that is the subject of the grant is conducted.
- This award mechanism allows Multi-PIs for projects that require a team science approach.
- For applications that include 1 PI, the PI is required to maintain a minimum 15% level of effort throughout the entire award period. For applications that include MIs, each PI is required to maintain a minimum 10% effort throughout the entire award period.
- A PI may not submit applications to this RFA and to RFA R-23.1-IIRA, RFA R-23.1- IIRACCA, RFA R-23.1-IIRACT, or RFA R-23.1-IIRAP during this funding cycle.
- A PI may submit only 1 application, either a new, resubmission or renewal application under this RFA during this funding cycle.
- A PI may be a part of only one application, whether as a single applicant or as part of a Multi-PI application, under this RFA and RFA R-23.1-IIRA, RFA R-23.1-IIRACCA, RFA R-23.1-IIRACT, or RFA R-23.1-IIRAP.
- An individual may serve as a PI on no more than 3 active CPRIT Academic Research grants. Recruitment Grants and Research Training Awards do not count toward the 3- grant maximum; however, CPRIT considers MIRA Project Co-PIs equivalent to a PI. For the purpose of calculating the number of active grants, CPRIT will consider the number of active grants at the time of the award contract effective date (for this cycle expected to be March 1, 2023).
- Collaborating organizations may include public, not-for-profit, and for-profit entities. Such entities may be located outside of the State of Texas, but non–Texas-based organizations are not eligible to receive CPRIT funds.
- An applicant is eligible to receive a grant award only if the applicant certifies that the applicant institution or organization, including the PI, any senior member or key personnel listed on the grant application, or any officer or director of the grant applicant’s institution or organization (or any person related to 1 or more of these individuals within the second degree of consanguinity or affinity), has not made and will not make a contribution to CPRIT or to any foundation specifically created to benefit CPRIT.
- An applicant is not eligible to receive a CPRIT grant award if the applicant PI, any senior member or key personnel listed on the grant application, or any officer or director of the grant applicant’s organization or institution is related to a CPRIT Oversight Committee member.
- The applicant must report whether the applicant institution or organization, the PI, or other individuals who contribute to the execution of the proposed project in a substantive, measurable way, regardless of whether these individuals are slated to receive salary or compensation under the grant award, are currently ineligible to receive federal grant funds or have had a grant terminated for cause within 5 years prior to the submission date of the grant application.
- CPRIT grants will be awarded by contract to successful applicants. Certain contractual requirements are mandated by Texas law or by administrative rules. Although applicants need not demonstrate the ability to comply with these contractual requirements at the time the application is submitted, applicants should make themselves aware of these standards before submitting a grant application.
For more information, visit CPRIT.
